Kinetics of thermal degradation of betamethasone valerate and betamethasone dipropionate in different media
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Kinetics of Thermal Degradation of Betamethasone Valerate and Betamethasone Dipropionate in Different Media
The effect of pH, media, phosphate concentration and ionic strength on the kinetics of thermal degradation of betamethasone valerate and betamethasone dipropionate has been investigated. A validated HPLC method has been used to determine the parent compounds and their major thermal degradation products identified in the reaction. Betamethasone-17-valerate gave rise to two major products, namely...
متن کاملDRUG PROFILE Calcipotriol/betamethasone dipropionate: Daivobet®/Dovobet®
10.2217/14750708.2.3.343 © 2 part of Psoriasis is a common skin condition that causes significant morbidity. Treatments can be complex and time consuming. Calcipotriol plus betamethasone dipropionate ointment (Daivobet® or Dovobet®) is a stable, convenient, once-daily topical treatment for psoriasis. Compared with its individual ingredients or tacalcitol, it has a faster speed of onset and grea...
متن کاملEfficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam Compared with Betamethasone 17-Valerate-Medicated Plaster for the Treatment of Psoriasis
BACKGROUND Fixed combination calcipotriol as hydrate (Cal) 50 µg/g plus betamethasone as dipropionate (BD) 0.5 mg/g aerosol foam is an alcohol-free treatment for psoriasis. Betamethasone 17-valerate 2.25 mg (BV)-medicated plasters are recommended for treating psoriasis plaques localized in difficult-to-treat (DTT; elbow, knee, anterior face of the tibia) areas. OBJECTIVE The aim of this study...
متن کاملCalcipotriol/betamethasone dipropionate in the treatment of psoriasis vulgaris
Psoriasis is one of the most common skin diseases. The mainstay of treatment for the vast majority of patients is topical therapy. A rising first-line treatment modality for psoriasis vulgaris is the two-compound ointment containing calcipotriol 50 mug/g plus betamethasone dipropionate 0.5 mg/g (Dovobet((R)), Daivobet((R)), Taclonex((R))), which combines a vitamin D analog and a corticosteroid....
متن کاملBetamethasone valerate compared with sodium cromoglycate in asthmatic children.
A double-blind, cross-over study was undertaken to compare inhalation of betamethasone valerate (BV, 800 microgram daily) with sodium cromoglycate (SCG, 80 mg daily) in twenty children requiring bronchodilators for perennial asthma. Each treatment period lasted 4 weeks but statistical comparisons were made only in respect of the last 14 days of each therapy. When the children were using BV they...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2012
ISSN: 0250-474X
DOI: 10.4103/0250-474x.103845